CRISPR/Cas9 genome editing system and its application in tumor therapy
10.3760/cma.j.issn.1673-422X.2018.09.010
- VernacularTitle:CRISPR/Cas9基因编辑技术及其在肿瘤治疗中的应用
- Author:
Yehuan YANG
1
;
Cheng-Wei YANG
;
Xiaoqing TAN
;
Xingchun GAO
Author Information
1. 710021,西安医学院基础医学部 陕西省脑疾病防治重点实验室
- Keywords:
Neoplasms;
Therapeutic uses;
CRISPR/ Cas9 genome editing technique
- From:
Journal of International Oncology
2018;45(9):556-560
- CountryChina
- Language:Chinese
-
Abstract:
CRISPR/ Cas9 gene editing system is a new tool of gene editing technology based on the im-mune mechanism of archaea against foreign nucleic acid invasion. Due to its high efficiency and accuracy, CRISPR/ Cas9 genome editing technology has been widely used in tumor therapeutic research,such as targeted knockout of oncogenes,repair of tumor suppressor genes,breaking immune tolerance,and construction of tumor models,which brings revolutionary development to tumor gene therapy.
