Association between metabolic syndrome and colorectal carcinoma based on a case-control study
10.3760/cma.j.issn.1673-422X.2018.09.006
- VernacularTitle:基于病例对照研究设计的代谢综合征与结直肠癌的相关性研究
- Author:
Ying LIAN
1
;
Linping WANG
;
Jing LIANG
;
Fang TANG
Author Information
1. 山东大学附属千佛山医院病案管理科
- Keywords:
Metabolic syndrome X;
Colorectal neoplasms;
Case-control studies
- From:
Journal of International Oncology
2018;45(9):539-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between metabolic syndrome and colorectal carcino-ma. Methods A total of 900 patients with colorectal carcinoma from 2013 to 2016 in Qianfoshan Hospital Af-filiated to Shandong University were selected as the case group and 1774 non-colorectal carcinoma participants from health management center as the control group. Logistic regression model was used to identify the relation-ship between metabolic syndrome and colorectal carcinoma. Results Compared with the controls (27. 0％), metabolic syndrome was more prevalent among cases (35. 4％). The difference was statistically significant (χ2 = 20. 33,P < 0. 01). Multivariate logistic regression analyses showed that metabolic syndrome as an entity increased colorectal carcinoma risk (OR = 1. 38,95％ CI:1. 08-1. 75,χ2 = 17. 68,P < 0. 01). Subjects with 2 and 3 or more components of the metabolic syndrome had an increased risk of colorectal carcinoma,and the ORs of colorectal carcinoma were 1. 37 and 1. 60,respectively. Gender-specific patterns were also observed in the association between metabolic syndrome,component and colorectal carcinoma (χ2 = 5. 40,P = 0. 02;χ2 =8. 66,P < 0. 01). Conclusion Metabolic syndrome is associated with the occurrence of colorectal carcinoma. An increasing trend in risk of colorectal carcinoma with the number of metabolic syndrome components is observed.
