Molecular mechanism in malignant progression of meningioma
10.3760/cma.j.issn.1673-422X.2018.08.010
- VernacularTitle:脑膜瘤恶性进展的分子机制
- Author:
Houjie LIU
1
;
Jinghai WAN
Author Information
1. 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院神经外科
- Keywords:
Meningioma;
Genetics;
Gene expression regulation;
Phenotype;
Biological markers
- From:
Journal of International Oncology
2018;45(8):494-498
- CountryChina
- Language:Chinese
-
Abstract:
Atypical and malignant meningiomas are characterized by high invasiveness and local recurrence.Traditional treatments such as surgery,radiotherapy and chemotherapy have limited effects.Recently,with the further study of the pathogenesis of meningioma and the development of molecular biology techniques,some new biomarkers have been found to play important roles in development and malignant progression of meningioma.Several genetic and epigenetic factors have been identified as contributing to the malignant progression of meningioma.Genetic factors include multiple phenotypic changes such as abnormal cell proliferation,increased cell invasiveness,angiogenesis,apoptosis inhibition,and changes in telomerase activity.And the discovery of biomarkers provides references for early diagnosis,molecular targeted therapy and prognosis assessment of high-grade meningiomas.
