Role of tumor-derived exosomes in tumor metastasis
10.3760/cma.j.issn.1673-422X.2018.07.009
- VernacularTitle:肿瘤细胞来源的外泌体在肿瘤转移中的作用
- Author:
Haiyan DONG
1
;
Xiaoyan PANG
;
Lei DOU
;
Fengxin LI
;
Dongli TIAN
;
Yi ZHANG
Author Information
1. 110001,中国医科大学附属第一医院妇科
- Keywords:
Neoplasm metastasis;
Tumor escape;
Neovascularization,pathologic;
Tumor-derived exosomes;
Neoplasm invasiveness
- From:
Journal of International Oncology
2018;45(7):427-431
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-derived exosomes (TEXs) are small membrane vesicles secreted by tumor cells.They contain various proteins and RNA which make they serve as functional mediators in cell interaction.TEXs can alter the components of extracellular matrix and induces epithelial-mesenchymal transition of tumor cells,which enhance the invasiveness of tumor cells.TEXs regulate immunity through multiple pathways,allowing circulating tumor cells to escape immune surveillance.TEXs promote pre-metastatic microenvironment in target organ before metastasis and induce angiogenesis after circulating tumor cells colonization.Understanding the role and mechanism of TEXs in this process can effectively block relevant signaling pathways which may provide new targeted therapies for clinic.
