Mechanism of microphthalmia family of transcription factors in tumorigenesis
10.3760/cma.j.issn.1673-422X.2018.05.009
- VernacularTitle:小眼畸形转录因子家族在肿瘤发生中的作用机制
- Author:
Wenyuan ZHUANG
1
;
Weidong GAN
Author Information
1. 210000,南京大学附属鼓楼医院泌尿外科
- Keywords:
Neoplasms;
Lysosomes;
Microphthalmia transcription factors
- From:
Journal of International Oncology
2018;45(5):292-295
- CountryChina
- Language:Chinese
-
Abstract:
Microphthalmia family of transcription factors (MiT/TFE) is very important for the regulation of cancer cell proliferation and energy metabolism.The MiT/TFE promotes the genesis and development of tumors by up-regulating the expression of lysosomal genes as well as acting on the oxidative metabolism and the oxidative stress response.MiT/TFE can also regulate lysosomal signaling including the mTORC1 and Wnt/3-catenin pathways.The relationship between MiT/TFE and folliculin (FLCN) is associated with the tumorigenesis.
