Notch signaling pathway in lung cancer and lung cancer stem cells and its inhibitors

VernacularTitle:Notch信号通路在肺癌和肺癌干细胞中的作用及其抑制剂
Author: Hengyao LIU ^{1
,

2} ; Guoli ZHAO ; Fuwen WANG ; Haibo CAI ; Yueying ZHANG
Author Information

1. 250200 济南大学山东省医学科学院医学与生命科学学院
2. 山东省医学科学院药物研究所国家卫生和计划生育委员会生物技术药物重点实验室山东省罕少见病重点实验室
Keywords: Receptors,Notch; Lung neoplasms; Neoplastic stem cells; Inhibitors
From: Journal of International Oncology 2018;45(4):250-252
CountryChina
Language:Chinese
Abstract: Notch signaling pathway is involved in the abnormal differentiation and self-renewal of lung cancer stem cells.The further studies for the roles of Notch signaling pathway in the regulation of lung cancer stem cells are expected to find new targets in the diagnosis and treatment of lung cancer.Inhibitors of the Notch signaling pathway may be effective in the treatment of lung cancer.Lung cancer stem cells are thought to be a major cause of recurrence of lung cancer,therefore,targeted therapy for lung cancer stem cells may be more effective than treatment for the entire tumor.