Clinicopathologicai characteristics and susceptibility genes of early-onset breast cancer

VernacularTitle:早发性乳腺癌的临床特征及遗传易感基因
Author: Lixi LI ¹ ; Fei MA
Author Information

1. 国家癌症中心中国医学科学院肿瘤医院肿瘤内科
Keywords: Breast neoplasms; Age of onset; Mutation; Genetic predisposition to disease
From: Journal of International Oncology 2018;45(4):241-244
CountryChina
Language:Chinese
Abstract: Early-onset breast cancer has aggressive clinicopathological characteristics and worse prognosis.However,there are few studies about it at home and abroad,which restricts the improvement of diagnosis and treatment level of breast cancer.Compared with older breast cancer,early-onset breast cancer has high mutation frequency and wide mutation spectrum.The study of unique susceptibility genes of early-onset breast cancer not only helps elucidate the difference of germline mutation spectrum between early-onset breast cancer and older breast cancer,but also will be helpful to study the diagnostic and prognostic marker for breast cancer,which provides evidence for screening and precision therapy.