Research progress of acetyl-CoA carboxylase in cancer metabolism

VernacularTitle:乙酰辅酶A羧化酶在肿瘤代谢中的研究进展
Author: Leihong DENG ^{1
,

2} ; Lifen PENG ; Tao ZENG ; Haichao CHAO
Author Information

1. 330006南昌,江西省人民医院泌尿外科
2. 南昌大学研究生院医学部
Keywords: Acetyl-CoA carboxylase; Cancer metabolism; Targeted molecular therapy
From: Journal of International Oncology 2018;45(4):234-237
CountryChina
Language:Chinese
Abstract: Abnormal fatty acid metabolism is one of the unique metabolic ways in which malignant cells maintain their growth needs and plays a crucial role in tumor progression.Acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme in fatty acid synthesis and oxidative metabolism.More and more researches confirm that ACC is highly expressed in many tumors,and is closely related to tumor progression and prognosis of patients,which makes ACC as a potential marker for clinical diagnosis and prognosis.Tumor cell fatty acid synthesis can be blocked and fatty acid β oxidation can be stimulated by inhibiting the activity of ACC,resulting in serious lipid consumption of tumor,and then inhibit tumor growth and proliferation.Investigating the effect and molecular mechanisms of ACC in the genesis and development of tumors can provide a new insight into cancer targeted molecular therapy.