Roles of Fibulin family members in the genesis and development of tumors
10.3760/cma.j.issn.1673-422X.2018.04.010
- VernacularTitle:Fibulin家族成员在肿瘤发生发展中的作用
- Author:
Xu LUO
1
;
Yunchen SUN
;
Liang ZHU
;
Jiangfeng HU
Author Information
1. 第二军医大学附属长征医院消化内科
- Keywords:
Neoplasms;
Extracellular matrix;
Fibulin
- From:
Journal of International Oncology
2018;45(4):229-233
- CountryChina
- Language:Chinese
-
Abstract:
The Fibulin family is a kind of secreted glycoprotein,belonging to the extracellular matrix protein.A total of 7 family members are widely distributed in basement membrane,elastic fiber and loose connective tissue.The Fibulin family is widely involved in the regulation of cell morphology,growth and adhesion.When Fibulin is disturbed,it can cause a range of diseases,such as skin laxity,tooth hypoplasia and various tumors.The researches show that Fibulin-1 is expressed abnormally in fibrosarcoma,gastric cancer and liver cancer,and the expression of Fibulin-2 is down-regulated in breast cancer and up-regulated in lung cancer.The other members of the family also show abnormal expression in various tumor tissues,which indicates the members of the Fibulin family play important roles in the genesis and development of tumors.
