Research progresses of lymphopenia induced T cell homeostatic proliferation in antitumor immunity
10.3760/cma.j.issn.1673-422X.2018.02.009
- VernacularTitle:淋巴细胞减少诱导的T细胞稳态增殖在抗肿瘤免疫治疗中的研究
- Author:
Nan LAI
1
;
Zehong CHEN
;
Zike YANG
;
Yanyouhong LIU
;
Shijun KANG
Author Information
1. 南方医科大学中西医结合医院肿瘤中心
- Keywords:
Cell proliferation;
Lymphopenia;
Immune tolerance
- From:
Journal of International Oncology
2018;45(2):100-102
- CountryChina
- Language:Chinese
-
Abstract:
Generally speaking,the organism can maintain the stability of T cells.The lymphopeniainduced homeostatic proliferation of T cells could be driven by the recognition of autoantigen including tumor antigen in the absence of foreign antigens or inflammatory signals.This process can break tumor-induced immune tolerance and induce a powerful antitumor immunity.It is confirmed that some negative immune molecules are recruited during the homeostatic proliferation,then the antitumor immunity will be impaired.
