Na +-K +-2Cl-cotransporter 1 and glioma
10.3760/cma.j.issn.1673-422X.2017.12.011
- VernacularTitle:钠钾氯共转运体1与胶质瘤
- Author:
Haiwen MA
1
;
Shengping YU
;
Xuejun YANG
Author Information
1. 300052,天津医科大学总医院神经外科
- Keywords:
Glioma;
Na +-K +-2Cl-cotransporter 1
- From:
Journal of International Oncology
2017;44(12):926-928
- CountryChina
- Language:Chinese
-
Abstract:
Na +-K +-2Cl-cotransporter 1 (NKCC1) is highly expressed in malignant gliomas,which is closely related to the degree of malignancy.NKCC1 protein has a vital function in the volume regulation of glioma cells.NKCC1 allows glioma cells to transform its volume freely,migrating through the narrow extracellular space to achieve distant metastases.There is also close relationship between NKCC1 and tumor cytoskeleton regulation.In addition,NKCC1 is closely associated with cell cycle,nerve activity and other biological functions.In conclusion,NKCC1 plays an important role in gliomas.
