Epigenetic regulation of epithelial-mesenchymal transition
10.3760/cma.j.issn.1673-422X.2017.12.009
- VernacularTitle:上皮间质转化的表观遗传调控
- Author:
Wenqing LI
1
;
Jinsong HOU
Author Information
1. 中山大学光华口腔医学院附属口腔医院口腔颌面外科广东省口腔医学重点实验室
- Keywords:
DNA methylation;
MicroRNAs;
Histone code;
Epithelial-mesenchymal transition
- From:
Journal of International Oncology
2017;44(12):918-921
- CountryChina
- Language:Chinese
-
Abstract:
The hallmark of epithelial-mesenchymal transition (EMT) is the loss of E-cadherin.The downregulation of E-cadherin can be mediated by its transcriptional repression through the binding of EMT transcription factors to the E-cadherin promoter.Epigenetic mechanisms including DNA methylation,histone code and microRNAs are involved in the regulation of EMT-related genes.Studies have shown that EMT transcription factors can cooperate with several epigenetic modifiers to participate in the expression of E-cadherin.Targeting epigenetic regulation of EMT represents a new promising therapeutic direction.
