Role of long non-coding RNA urothelial carcinoma associated antigen 1 as a competing endogenous RNA in the regulation of the initiation and progression of tumor

VernacularTitle:长非编码RNA UCA1作为竞争性内源RNA在调控肿瘤发生发展中的作用
Author: Shuming GU ¹ ; Min XU
Author Information

1. 江苏大学附属医院消化内科
Keywords: Neoplasms; Long non-coding RNA; Urothelial carcinoma associated antigen 1; Competing endogenous RNA
From: Journal of International Oncology 2017;44(12):911-913
CountryChina
Language:Chinese
Abstract: Long non-coding RNA urothelial carcinoma associated antigen 1 (UCA1) is highly expressed in multiple types of tumors,such as bladder cancer,breast cancer,colorectal cancer and so on.Recent studies show that UCA1 can interact with the microRNAs as a competing endogenous RNA (ceRNA),to indirectly regulate the expression of target genes,and then participates in the regulation of the initiation and progression of tumor.Therefore,using the mechanism of ceRNA to intervene the expression of UCA1 will provide new ideas for tumor treatment.