ROS1 fusion gene in targeted therapy of non-small cell lung cancer

VernacularTitle:ROS1融合基因在非小细胞肺癌靶向治疗中的研究进展
Author: Xin CHUANG ¹ ; Bo JIN
Author Information

1. 中国医科大学附属第一医院肿瘤内科
Keywords: Carcinoma,non-small-cell lung; ROS1 fusion gene; Crizotinib; Molecular targeted therapy
From: Journal of International Oncology 2017;44(10):783-786
CountryChina
Language:Chinese
Abstract: The molecular target therapy of non-small cell lung cancer (NSCLC) has become a hot research direction in the field of medicine.Following the discovery of well-known tumor-driven genes such as epidermal growth factor receptor (EGFR),Kirsten rat sarcoma viral oncogene (KRAS) and anaplastic lymphoma kinase (ALK) genes,more and more scholars have shifted focus to ROS1 fusion gene.The protein encoded by ROS1 is a member of the receptor tyrosine kinase super family,and it plays an important role in cell growth and cell survival.ROS1 fusion gene plays a vital role in the occurrence,development and clinical treatment of NSCLC.