Application of circulating tumor DNA in endocrine therapy resistance of breast cancer
10.3760/cma.j.issn.1673-422X.2017.10.014
- VernacularTitle:循环肿瘤DNA在乳腺癌内分泌治疗耐药中的应用
- Author:
Binliang LIU
1
;
Fei MA
;
Yixin ZENG
Author Information
1. 100021,北京协和医学院中国医学科学院肿瘤医院肿瘤内科
- Keywords:
Breast neoplasms;
Endocrine therapy;
Circulating tumor DNA
- From:
Journal of International Oncology
2017;44(10):779-782
- CountryChina
- Language:Chinese
-
Abstract:
Although most hormone-receptor positive breast cancer patients initially respond to endocrine treatment,they will eventually acquire resistance to endocrine therapy.Therefore,during clinical treatment,it is of great importance to continuously monitor for resistant mutations.Circulating tumor DNA (ctDNA) has become more prevalent because it is non-invasive,convenient,rapid,and can quickly assess the overall situation of the tumor.With the maturity of next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR),the establishment of endocrine treatment resistance mutation monitoring system has become possible.
