Warburg effect on tumor
10.3760/cma.j.issn.1673-422X.2017.10.010
- VernacularTitle:Warburg效应在肿瘤中的研究进展
- Author:
Yuhui ZHOU
1
;
Jiufeng WEI
;
Guodong LI
;
Ming LIU
Author Information
1. 150001,哈尔滨医科大学附属第四医院普外科普外科生物样本库
- Keywords:
Glycolysis;
Neoplasms;
Universal precautions;
Therapy;
Warburg effect;
Molecular mechanism
- From:
Journal of International Oncology
2017;44(10):762-766
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cells can escape from the normal apoptosis process and enhance the ability of proliferation and migration via an abnormal glucose metabolism.This abnormal glucose metabolism is named the Warburg effect,which plays a key role in the incidence of tumor.The Warburg effect is that,under aerobic condition,attenuating aerobic respiration of tumor cells via a series of molecular mechanisms,and exhibiting higher glycolysis metabolism and adenosine triphosphate (ATP) production,and meanwhile,creating the micro-environment that suitable for tumor cell survival,inducing proliferation advantages for tumor cells.In addition,the Warburg effect-induced regional hypoxia reduces monitoring effect and lethality of T-lymphocytes,and thus induces immune escape of tumor cells.By inhibiting related pathways of Warburg effect,some drugs such as 2-deoxy-D-glucose and dichloroacetic acid have effective ability to inhibit Warburg effect-caused proliferation advantages and immune escape of tumor cells,and thus inhibit tumor cells growth and promote tumor cells death.Moreover,health diet also effectively inhibits the Warburg effect.However,there are also some problems to be solved.As the development of researches on the Warburg effect,the effect of various antitumor drugs will be revalued,and these will provide new theoretical basis and research direction for tumor prevention and therapy.
