Reversal of P-glycoprotein-mediated multidrug resistance mechanism by curcumin

VernacularTitle:姜黄素逆转P-糖蛋白介导的多药耐药机制
Author: Lan LIU ¹ ; Zhimin ZHANG ; Wenmiao PENG ; Hongxing FU ; Zhiguo RAO
Author Information

1. 广州军区武汉总医院肿瘤科
Keywords: Curcumin; P-glycoprotein; Multidrug resistance; Signal path
From: Journal of International Oncology 2017;44(10):758-761
CountryChina
Language:Chinese
Abstract: Muhidrug resistance (MDR) is one of the important reasons for the failure of clinical anticancer drugs,involving multiple mechanisms.Among them,the classical MDR mechanism mediated by P-glycoprotein (P-gp) is closely related to the formation of MDR,which can excrete intracellular chemotherapeutic drugs through the "drug pump" effect and significantly reduce the therapeutic effect.Curcumin is mainly extracted from the underground rhizome of Chinese medicine turmeric,with a wide range of pharmacological activity.Recent studies have found that curcumin also has a role in reversing the MDR of the tumor,by inhibiting both P-gp function and expression,and this process involves a variety of signal paths.