Anticancer properties of fenofibrate
10.3760/cma.j.issn.1673-422X.2017.09.010
- VernacularTitle:非诺贝特的抗肿瘤作用
- Author:
Yating SHEN
1
;
Duanmin HU
Author Information
1. 215004,苏州大学附属第二医院消化科
- Keywords:
Procetofen;
Neoplasms;
Apoptosis;
Cell cycle
- From:
Journal of International Oncology
2017;44(9):682-685
- CountryChina
- Language:Chinese
-
Abstract:
Fenofibrate is a common lipid-lowing drug activating peroxisome proliferator-activated receptor alpha (PPRAα).Recent studies have found that fenofibrate possesses anticancer properties.Its specific mechanisms include inhibiting cell metabolism and formation of new tumor vessels,arresting cell circle,weakening cell motility,and inducing cell apoptosis.Those properties are partly independent of PPRAα.Due to its low side-effects,it's hopefully to be used as an anticancer adjuvant drug.
