Research advances of LINE-1 in tumor
10.3760/cma.j.issn.1673-422X.2017.09.008
- VernacularTitle:LINE-1在肿瘤研究中的新进展
- Author:
Meiling TANG
1
;
Jianxin WU
;
Huibo CHANG
Author Information
1. 首都儿科研究所生物化学室
- Keywords:
Neoplasms;
Methylation;
Retroelements;
Long interspersed nuclear element-1
- From:
Journal of International Oncology
2017;44(9):676-678
- CountryChina
- Language:Chinese
-
Abstract:
The abnormality of long interspersed nuclear element-1 (LINE-1) is closely related to the occurrence and development of tumor.Overexpression of LINE-1 can promote cell proliferation and affect the prognosis and metastasis of tumor.The retrotransposition and methylation status of LINE-1 have potential application value in clinical diagnosis,prognosis,disease monitoring and treatment.
