Curcumin hydrogel combined with photodynamics to treat acne
10.13220/j.cnki.jipr.2017.12.008
- VernacularTitle:基于光动力学姜黄素水凝胶治疗痤疮的疗效评价
- Author:
Hai-Ying QIU
1
;
Hai-Yan BI
;
Xiao CHEN
;
Pei-Pei MA
;
Wen-Yuan CHEN
;
Li-Na DU
;
Yi-Guang JIN
Author Information
1. 军事科学院军事医学研究院放射与辐射医学研究所药剂学研究室
- Keywords:
curcumin;
hydrogel;
photodynamics;
acne
- From:
Journal of International Pharmaceutical Research
2017;44(12):1125-1130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To demonstrate the therapeutic effect of curcumin hydrogel combined with photodynamics on acne. Methods Sieving and ultrasound/high pressure homogenization were used to prepare curcumin micropowder.Curcumin-loaded hydro?gel was prepared with Poloxamer 407 and its rheological characteristics were evaluated.The antibacterial activity of curcumin hydrogel irritated with 657 nm laser was assayed by a hole-punching method.Acne model on rabbit ears war established.Fifteen New Zealand white rabbits were randomly divided into five groups:the model group,tretinoin cream group,illumination group,curcumin hydrogel group,and curcumin hydrogel/illumination group.The therapeutic effects on acne were evaluated by the morphological and histopatho?logical examination.Results The micropowdered curcumin prepared with ultrasound/high pressure homogenization had smaller size and more uniform distribution(size range:5-20 μm.)than the sieving-prepared curcumin micro-powders(10-45 μm).The prepared hydrogels being a pseudoplastic fluid had the properties of gelatin.The antibacterial effect of curcumin hydrogel/illumination was bet?ter than that of curcumin hydrogel.The inhibition zone diameters were(9.4±0.92)and(12.57±1.12)mm for the curcumin hydrogel and the curcumin hadrogel/illumination groups,respectively.The therapeutic effect for the treatment of acne on the rabbit ears with ac?ne was better in the curcumin hydrogel/illumination group than in both the illumination and the curcumin hydrogel groups. Conclu?sion Curcumin hydrogel combined with photodynamic therapy showed better therapeutic efficacy on acne treatment.It provides an ideal choice for acne treatment.
