Mechanism of anti-endotoxemia based on LPS-TLR4 signaling pathway:research advances

VernacularTitle:基于脂多糖-Toll样受体4信号通路抗内毒素血症机制研究进展
Author: Cheng-Cheng DU ^{1
,

2} ; Ting YIN ; Ru-Jing REN ; Xiao-Qiang LI ; Jian-Ying SHEN ; Yu-Qing TAN
Author Information

1. 550025贵阳,贵州医科大学
2. 100029北京,中国中医科学院中药研究所
Keywords: Toll-like receptors(TLR)4; signal transduction; endotoxemia; mechanism
From: Journal of International Pharmaceutical Research 2017;44(12):1107-1112
CountryChina
Language:Chinese
Abstract: Toll-like receptors 4(TLR4),an important member of the TLR family,is considered as gene encoding LPS recep?tors,and major receptors for identifying lipopolysaccharide(LPS).LPS-induced TLR4 signaling pathway plays a key role in endotox?emia.After TLR4 activated by LPS,the mitogen-activated protein kinase(MAPK)signaling pathway and nuclear transcription factor κB(NF-κB)are activated and large amounts of inflammatory factors are released,triggering inflammatory cascade reaction.This arti?cle reviews the mechanisms of endotoxemia in treatment based on TLR4 signal pathway in three perspectives:the effects of LPS-TLR4 signaling pathway on the upstream target proteins,LPS-induced TLR4 signal transduction,and the downstream target proteins regulat?ed by LPS-TLR4 signaling pathway.