Wnt signaling pathway in the neural stem cell proliferation and the herbal medicine intervention:research progress
10.13220/j.cnki.jipr.2017.12.002
- VernacularTitle:神经干细胞增殖的Wnt信号通路及中药干预的研究进展
- Author:
Shu-Ran LI
1
;
Ran DENG
;
Qing-Shan LIU
Author Information
1. 中央民族大学药学院教育部重点实验室
- Keywords:
neural stem cells;
sequelae of cerebral ischemia;
Wnt signaling pathway;
innovative drugs
- From:
Journal of International Pharmaceutical Research
2017;44(12):1089-1092
- CountryChina
- Language:Chinese
-
Abstract:
The characteristics of self-renewal and multilineage differentiation potential of neural stem cells(NSC)provide a new strategy for the treatment of ischemic brain sequelae.It is of great significance to find out new drugs that regulate the proliferation of endogenous NSC for the damage of nerve cells and the change of microenvironment in the brain.This review summarizes the prog?ress of Wnt signaling pathway in regulating NSC proliferation,related drug targets and the current research status of Chinese herbal medicines in regulating NSC proliferation,in order to provide a reference for future studies on new drugs for the prevention and treat?ment of ischemic brain sequelae.
