Design and synthesis of anti-HCV drug sofosbuvir:research advances

VernacularTitle:抗丙型肝炎药物索磷布韦的设计合成研究进展
Author: Xue-Feng SHOU ¹ ; Zhen-Jun WANG ; Xiao-Feng CHENG ; Cai-Xia HUO
Author Information

1. 内蒙古医科大学药学院
Keywords: sofosbuvir; NS5B polymerase inhibitor; direct-acting antiviral(DAA)drugs; anti-HCV drugs
From: Journal of International Pharmaceutical Research 2017;44(10):918-924
CountryChina
Language:Chinese
Abstract: Sofosbuvir is a new type of direct-acting antiviral(DAA)drugs against hepatitis C.By competitive combination to NS5B polymerase activity sites,sofosbuvir can terminate genome synthesis of newly born virus,and finally inhibit the replication of hepatitis C virus(HCV).The research and development process of sofosbuvir is based on the principles of nucleoside antiviral drug metabolism.The subtle structure modification improves the drug′s structure stability and absorption process,which makes sofosbuvir a liver targeted anti-HCV drug.Sofosbuvir has become a clinical fundamental drug for anti-HCV infection,and then used alone or in combination with other drugs,with higher recovery rate,better safety and anti-drug resistance.This article reviews the research back?ground,development process,clinical application and synthetic methods for sofosbuvir.