The molecular mechanisms and potential drug targets to regulate neural stem cells migration
10.13220/j.cnki.jipr.2017.10.002
- VernacularTitle:调控神经干细胞迁移的分子网络机制与潜在药物靶点
- Author:
Ran DENG
1
;
Shu-Ran LI
;
Qing-Shan LIU
Author Information
1. 中央民族大学药学院
- Keywords:
neural stem cell;
migration;
cytokine;
signal pathway;
drug target
- From:
Journal of International Pharmaceutical Research
2017;44(10):914-917
- CountryChina
- Language:Chinese
-
Abstract:
At the moment,neural stem cells(NSC)therapy is one of the main means to improve stroke and neurodengenera?tive disease. This paper analyses the key molecular targets that promote NSC migration,such as chemokines,brain-derived neuro?trophic factor and vascular endothelial growth factor,and clarifies the relationships as well as important nodes between pathways,like PI3K/Akt,MAPK/ERK,and JAK/STAT.It is helpful to understand the molecular network mechanisms of NSC migration and provide ideas and targets to design creative drugs to promote NSC migration.
