Optimization of extraction process of total flavonoids fromCibotium barometz by design-response surface method

VernacularTitle:响应面分析法优选金毛狗脊总黄酮提取工艺
Author: Yi SUN
Keywords: Cibotium barometz; total flavonoids; extraction technique; response surface method
From: Journal of International Pharmaceutical Research 2017;44(9):901-904
CountryChina
Language:Chinese
Abstract: Objective To optimize the extraction conditions for total flavonoids from Cibotium barometz by response surface meth-od(RSM). Methods According to the center combination of Box-Benhnken,using the RSM,the effects of ethanol concentration,the ratio of solid to liquid,the extraction time,and the extraction frequency were studied by central composite design. Results The opti-mal conditions of extraction were as follows:60％ethanol,the ratio of solid to liquid 1:40,refluxing and extracting twice,and 1.5 h for each time. Conclusion The actual extraction yield was 1.44％. The method of extraction has higher extraction efficiency than other methods and can provide a basis for the industrial production of the total flavonoids from S. barometz.