Asymmetric oxidation synthesis of esomeprazole sodium:research advances
10.13220/j.cnki.jipr.2017.09.008
- VernacularTitle:埃索美拉唑钠不对称氧化合成工艺的研究进展
- Author:
Yong-Fei REN
1
;
Ran FU
;
Jin-Feng LIU
;
Wei-Na HAN
Author Information
1. 哈尔滨医科大学药学院
- Keywords:
esomeprazole;
synthesis process;
asymmetric oxidation;
metal complex catalyst;
hydrogen peroxide
- From:
Journal of International Pharmaceutical Research
2017;44(9):867-870
- CountryChina
- Language:Chinese
-
Abstract:
Esomeprazole sodium is a widely used proton pump inhibitor which is mainly applied to the treatment of gastric ul-cer,duodenal ulcer,digestive esophagitis and gastritis. By reviewing the literature over the past decade on the asymmetric oxidation of esomeprazole sodium ,the paper summarizes the synthetic process and focuses on the comparison of the critical steps. To choose suit-able chiral catalyst to reduce the cost of synthesis of esomeprazole sodium,this paper compares beyond the yield,enantioselectivity and other aspects. The conclusion is that the catalysts used in the most of oxidation systems are with a large load and high cost ,and compared with the classical Kagan-Modena system,the Ti-salan catalyst has advantages in the synthesis of esomeprazole sodium,and can be widely used.
