CADY-based cell penetrating peptides as siRNA delivery vector:research progress

VernacularTitle:CADY细胞穿膜肽作为siRNA递送载体的研究进展
Author: He ZHANG ¹ ; Yue HU ; Zhou CHEN ; Zheng HOU ; Ming-Kai LI ; Xiao-Yan XUE
Author Information

1. 中国人民解放军第四军医大学学员一旅五连
Keywords: RNA,small interfering; cell-penetrating peptides; CADY-1 peptide
From: Journal of International Pharmaceutical Research 2017;44(9):845-850
CountryChina
Language:Chinese
Abstract: How to deliver small interfering RNA(siRNA)molecules into target cells efficiently and safely to silence target genes is a bottleneck in the clinical application of RNA interference. In recent years,siRNA delivery technology based on cell pene-trating peptides has developed rapidly. Among them,the secondary amphipathic peptide,called CADY,has little cytotoxicity and no immunogenicity,forms stable siRNA complexes and improves their delivery into a wide variety of cell lines. Therefore,it has become a very promising delivery carrier for siRNA applications. This review summarizes the design idea,structural characteristic,spatial con-figuration,internalization mechanism,modification and application of CADY.