Pharmacological effects on the central nervous system and toxicity of cordycepin:research advances
10.13220/j.cnki.jipr.2017.09.004
- VernacularTitle:虫草素的中枢神经系统作用及毒性研究进展
- Author:
Xin-Xia GU
1
;
Xiao-Qun GE
Author Information
1. 扬州大学医学院药理教研室
- Keywords:
cordycepin;
sedation and hypnosis;
learning and memory;
neuroprotection;
toxicity
- From:
Journal of International Pharmaceutical Research
2017;44(9):840-844
- CountryChina
- Language:Chinese
-
Abstract:
Cordycepin(3′-deoxyadenosine),a derivative of the nucleoside adenosine,is a major functional component of Cordyceps militaris. It has been found that cordycepin possesses a variety of pharmacological activities,such as antibacterial,antivial, antiinflammatory,antitumor,immunoregulation,hypolipidemic,and hypoglycemic activities. In recent years,the effects of cordyce-pin on the central nervous system(CNS)have attracted great attention,and it has been found that cordycepin could not only affect the function of the CNS but also protect nerves from injuries. This paper reviews the effects of cordycepin on sedation and hypnosis ,the im-provement of learning and memory,and the protection of nerve injuries caused by cerebral ischemia/hemorrhage ,nerve toxin(gluta-mate,β-amyloid,rotenone and 6-hydroxydopamine,etc.),lipopolysaccharide and trauma,along with the in vitro toxicity as well as acute and subacute in vivo toxicity,so as to offer valuable references for future study and application of cordycepin.
