Possible mechanism of cellular acidification in epilepsy termination

VernacularTitle:细胞酸化在癫痫终止中的可能作用机制
Author: Zhi-Guo WANG ¹ ; Yi PAN
Author Information

1. 广州中医药大学基础医学院
Keywords: cellular acidification; epileptic termination; mechanism
From: Journal of International Pharmaceutical Research 2017;44(9):823-827
CountryChina
Language:Chinese
Abstract: Epilepsy,especially the status epilepticus(SE),is a kind of common disease which is seriously dangerous for peo-ple′s health. At present,many researchers are focusing on how the epilepsy seizures happen and maintain,but know little about how it stops. It was found that appropriate cell acidification played an important role in patients to slow down or inhibit epilepsy-like seizures in the early 20th century. Recently,more and more researches have confirmed that cell acidification can induce the termination of epi-leptic seizure caused by disbalance of inhibitory and excitatory transmitters of nerve,opening of acid-sensing ion channels and so on. Therefore,these will likely become the new direction to explore new drugs or methods for epileptic treatment in the future.