Latest research progress of periprosthetic osteolysis mechanism and related signaling pathway

VernacularTitle:假体周围骨溶解机制及相关信号通路的最新研究进展
Author: Huimin LIU ¹ ; Yafei WANG ; Yunjian LIAO ; Yongyun LIAN ; Feng DONG ; Daifeng LU ; Hongxi LI ; Zhitao ZHANG
Author Information

1. 150001,哈尔滨医科大学附属第四医院骨科
Keywords: Osteolysis; Signal Pathway; Mechanism
From: International Journal of Surgery 2018;45(11):773-779
CountryChina
Language:Chinese
Abstract: Artificial joint replacement is an important means for the treatment of severe joint end-stage diseases such as hip and knee joint,which has obtained satisfactory clinical efficacy,but the postoperative periprosthetic osteolysis (PPO),which is mediated by wear particles,restricts the long-term effect of artificial joints.It is found that wear particles increase the expression of cytokines and inflammatory factors by stimulating the cells around the prosthesis,activate different signaling pathways,promote the imbalance between bone formation mediated by local osteoblasts and bone resorption mediated by osteoclast so as to lose of the local bone mass,and eventually produce osteolysis and aseptic loosening.This article reviews the different signal pathways activated by wear particles in recent years,in order to explore the pathogenesis of PPO and to open up new avenues for its prevention and treatment.