Clinical diagnosis and treatment of five cases with malignant tumors associated with Peutz-Jeghers syndrome
10.3760/cma.j.issn.1673-4203.2018.10.006
- VernacularTitle:黑斑息肉综合征继发恶变五例诊疗研究
- Author:
Guojun WANG
1
;
Zhi ZHENG
;
Peixin LI
;
Shengqi QIN
;
Jin WANG
;
Jianshe LI
;
Zhongtao ZHANG
Author Information
1. 100050,首都医科大学附属北京友谊医院普外科
- Keywords:
Neoplasms;
Surgical procedures,operative;
Diagnosis;
Treatment outcome;
Peutz-Jeghers syndrome
- From:
International Journal of Surgery
2018;45(10):669-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical characteristics,diagnosis and treatment method after Peutz-Jeghers Syndrome (PJS) secondary malignant.Methods The clinical date of five cases with malignant tumors associated with Peutz-Jeghers syndrome from June 2014 to January 2017 were analyzed retrospectively in Beijing Friendship Hospital,Capital Medical University.The patients were followed up by phone,outpatient service,and hospitalization.The starting point of the follow-up was the visit date.The patient's death was the end point.The clinical and pathological features,therapy,and postoperative survival were observed.The follow-up deadline was May 2018.Results PJS secondary malignant patients lack clinical specificity.Two cases of five patients accepted endoscopic resection,three cases accepted surgery,and were treated with chemotherapy postoperatively,including 1 case died from tumor progression of 6 months after operation.Tumor recurrence was not found in the rest 4 cases till May 2018.Conclusions Part of the malignant polyp,endoscopic resection is feasible.When endoscopic resection is not feasible,operation treatment is needed;and postoperative adjuvant chemotherapy is needed to improve the long-term prognosis.
