Efficacy comparison of interstitial cystitis/painful bladder syndrome patients treated with oral medication and Sodium hyaluronate intravesical instillation
10.3760/cma.j.issn.1673-4203.2018.09.008
- VernacularTitle:口服药物与透明质酸钠灌注治疗间质性膀胱炎/膀胱疼痛综合征的疗效对比
- Author:
Yinchao MA
1
;
Zhengsen CHEN
;
Yunpeng SHAO
;
Sicong ZHANG
;
Baixin SHEN
;
Liucheng DING
;
Zhongqing WEI
Author Information
1. 215000,南京医科大学附属医院苏州明基医院泌尿外科
- Keywords:
Cystitis;
Interstitial;
Drug therapy;
Sodium hyaluronate
- From:
International Journal of Surgery
2018;45(9):603-607,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the outcomes between interstitial cystitis/bladder pain syndrome (IC/BPS)patients treated with three-drug combination (M blockers + alpha blockers + Amitriptyline) and Sodium hyaluronate intravesical instillation.Methods The patients who came to Second Affiliated Hospital of Nanjing Medical University during October 2014 to September 2015 were investigated if they had IC/BPS.According to the treatment plan,27 patients (group A) received three-drug combination (M blocker + alpha blockers + Amitriptyline)therapy.Thirty-eight patients recelved instillation of sodium hyaluronate (40 mg/50 ml) therapy (group B).Intravesical instillations were performed weekly in the first 6 weeks,and monthly until sixth month.Interstitial cystitis symptom index,interstitial cystitis problem index,overactive bladder symptom score,visual analogue scale/score,the maximum urination and self-rating depression scale were assessed at baseline and the sixth month.Measurement data were expressed as ((x) ±s),t test was used for comparison between groups,and paired t-test was used for comparison of paired data.Results There were 65 patients.Age range was 25-73 years,course of disease (2-99 months),average age (51.4 ± 13.5),average duration (39.8 ± 31.0) months,of which 9 male (13.8％) and 56 female (86.2％) patients.The group A variation of ICSI、ICPI、OABSS、VAS、SDS and maximum urination were 3.7 ± 2.4、1.3 ± 1.5、1.2 ± 1.3、2.1 ± 1.5、3.1 ± 4.5、74.6 ± 52.4,The variation of group B ware 6.8 ± 3.6、5.0 ± 3.8、2.5 ± 1.8、2.8 ± 1.7、8.9 ± 6.4、109.0 ± 81.1.The improvement in ICSI,ICPI,OABSS,SDS of group B were higher than group A (P ＜ 0.05).Conclusion IC/BPS seriously affect the quality of life and the patients are prone to depression.The sodium hyaluronate intravesical instillation therapy could achieve more effect than the three-drug combination therapy.
