Relationship between gastrointestinal tumor and non-B cell derived immunoglobulins
10.3760/cma.j.issn.1673-4203.2018.08.013
- VernacularTitle:非B细胞来源免疫球蛋白与消化系统肿瘤研究进展
- Author:
Chunxiang YE
1
;
Zhanlong SHEN
;
Hongpeng JIANG
;
Wei ZHANG
;
Yingjiang YE
;
Shan WANG
Author Information
1. 100044,北京大学人民医院胃肠外科 外科肿瘤研究室结直肠癌诊疗研究北京市重点实验室
- Keywords:
Immunoglobulins;
Non-B cell;
Digestive system neoplasms;
Immunity;
Malignant tumors
- From:
International Journal of Surgery
2018;45(8):552-556
- CountryChina
- Language:Chinese
-
Abstract:
B lymphocytes are not the only source of Igs,instead,various non-B cell types,including the normal epithelial cells and cancer cells,also own the ability to produce different types of Igs.The non-B cell derived Igs possess their own characteristics.For instance,they are highly conserved in V (D)J rearrangement patterns;each Ig has its own rearrangement pattern of the variable region of IgH.The non-B Igs are closely related with tumors.They are highly expressed in different tumors,including clear cell renal cell carcinoma,lung cancer,breast cancer,and they act as a tumor promoter through different mechanisms.As to the digestive system tumors,several digestive organs or their corresponding tumors could produce Igs,such as stomach,liver,pancreas,small intestine and colon.The Igs derived from these organs may participate in the innate immune responses,as well as the tumorigenesis processes.A more detailed study on the non-B cell derived Igs may provide new therapeutic targets for malignant tumors,including tumors from digestive system.
