Rapeutic evaluation of 30 cases of perianal fistulising Crohn's disease who were removed setons at fixed time
10.3760/cma.j.issn.1673-4203.2018.08.010
- VernacularTitle:30例克罗恩病肛瘘患者定时拆线的疗效评价
- Author:
Minmin XU
1
;
Hao WANG
;
Youran LI
;
Yunfei GU
Author Information
1. 江苏省中医院肛肠科
- Keywords:
Rectal fistula;
Treatment outcome;
Drainage;
Crohn's disease;
Infliximab;
Seton
- From:
International Journal of Surgery
2018;45(8):543-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the time of removing setons by observing 30 cases of the infliximab (IFX)combined drainage setons therapy in the treatment of perianal fistulising Crohn's disease.Methods Thirty patients of perianal fistulising Crohn's disease of Department of Colorectal Surgery,Jiangsu Prorince Hospital of TCM in Aug.2015 to Jul.2017 were treated with drainage setons followed by intravenous IFX injections according to the standard,and setons were removed after the third injection of IFX.The method of repeated measurement were adopted to record.Clinical symptoms,perianal manifestations,laboratory indexes,healing rate and general linear model and nonparametric test of SPSS 23.0 software were used for statistical analysis.Results The differences of WBC,CRP,ESR,HB,PLT,BMI,CDAI and PDAI between post treatment and pretreatment were statistically significant (P ＜ 0.05).WBC,CRP and ESR will rerise at some time after removing the rubber band (sixth week).The closure rate of fistular at the 14th week was 53.3％,and after the follow-up in the ward at 22th week and 30th week,the clinical efficacy of fistular was not statistically significant (P ＞0.05) at the 14th week,22th week and 30th week.Conclusion IFX combined drainage setons which was removed when the induction therapy finished can induce Crohn's disease remission,improve laboratory index and promote fistula closure.the clinical efficacy in short time was stable.
