Predicting value of PDGF-BB combined with CLIF-COFs for the occurrence of ARDS in post-liver transplantation patients
10.3760/cma.j.issn.1673-4203.2018.08.007
- VernacularTitle:PDGF-BB结合CLIF-COFs肝移植术后发生ARDS的预测价值
- Author:
Qingliang GUO
1
;
Shichun LU
;
Binwei DUAN
;
Daobing ZENG
;
Liang DI
;
Dongdong LIN
Author Information
1. 100069,首都医科大学附属北京佑安医院普外中心
- Keywords:
Liver transplantation;
Respiratory distress syndrome,adult;
Cytokines;
Platelet-derived growth factor BB;
Acute-on-chronic liver failure
- From:
International Journal of Surgery
2018;45(8):528-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of cytokines combined with CLIF consortium organ failure score (CLIF-COFs) for predicting the occurrence of acute respiratory distress syndrome (ARDS) in for post-liver transplant for hepatitis B-related acute-on-chronic liver failure (HB-ACLF) patients.Methods From Jul.2014 to Oct.2017,there were 37 cases of HB-ACLF undergoing liver transplantation in Beijing YouAn Hospital,Capital Medical University.According to whether the patients happened ARDS or not,37 cases were divided into ARDS group (n =9) and non-ARDS group (n =28).All patients' plasma was prospectively collected immediately before liver transplantation and on the I st,3rd,5th,7th day post-liver transplantation.The serum levels of twenty-seven cytokines were determined by 200 LUMINEX liquid chip technology.Cytokines,CLIF-COFs,clinical and biochemical indexes were analyzed with logistic regression and the receiver operating characteristic (ROC) to confirm the correlation with ARDS post liver transplantation.Results There were significant differences between HB-ACLF patients between ARDS group and non-ARDS group in age and pre-transplant infection (P ＜ 0.05).The CLIF-COFs was higher in ARDS non-without than that in non-ARDS group (P =0.019).The serum levels of vascular endothelial growth factor and platelet-derived growth factor bb were lower but IL-6 was higher post transplantation in ARDS group.The COX analysis indicated that CLIF-COFs and post liver transplantation PDGF-BB were predictors of post-LT ARDS.The area under the receiver operating characteristic (AUROC) curves was 0.728 and 0.175,respectively.The area under the curve of the discriminatory power of CLIF-COFs combined with PDGF-BB was 0.913,and the maximum Youden index is 0.786.Conclusion CLIF-COFs combines with PDGF-BB can predict the occurrence of ARDS post-liver transplantation in HB-ACLF patients.
