Research progress on heterogeneity and epigenetics of hepatocellular CarCinoma
10.3760/cma.j.issn.1673-4203.2018.06.015
- VernacularTitle:肝细胞肝癌异质性与表观遗传学研究进展
- Author:
Jun CAO
1
;
Dousheng BAI
;
Guoqing JIANG
;
Chi ZHANG
Author Information
1. 中南大学湘雅二医院肝胆外科
- Keywords:
Liver neoplasms;
Genetic heterogeneity;
Neoplastic stem cells;
Epigenetics
- From:
International Journal of Surgery
2018;45(6):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Tumor heterogeneity is one of the common phenomena of malignant tumors, and the heterogeneity of hepatocellular carcinoma is significant. Despite some treatments such as surgical resection, chemotherapy and radiotherapy in the primary phage of hepatocellular carcinoma have been used, the prognosis of patients remains poor, which is closely related to the heterogeneity of hepatocellular carcinoma. Therefore, exploring the heterogeneity of hepatocellular carcinoma has important clinical significance for improving the therapeutic effect of hepatocellular carcinoma. This article reviews the heterogeneity of hepatocellular carcinoma from an epigenetic perspective and explores the possible intrinsic epigenetic molecular mechanisms underlying the heterogeneity of hepatocellular carcinoma.
