Immunotherapy of pancreatic cancer and the application of DNT cell in the therapy of pancreatic cancer
10.3760/cma.j.issn.1673-4203.2018.05.015
- VernacularTitle:胰腺癌的免疫治疗及DNT细胞在其治疗中的应用
- Author:
Gaohua WU
1
;
Jiong CHEN
Author Information
1. 安徽医科大学附属省立医院普外科
- Keywords:
Pancreatic neoplasms;
Immunomodulation;
Immunotherapy;
DNT cells
- From:
International Journal of Surgery
2018;45(5):349-352
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a kind of malignant tumor with a high degree of malignancy and a very poor prognosis.The onset is occult,early metastasis is easy,and progression is rapid.Despite clinically increasing the resection rate of pancreatic cancer,the survival time after surgery is not significantly prolonged.Pancreatic cancer is not sensitive to radiotherapy and chemotherapy,so there is no effective treatment.Adoptive immunotherapy is an important auxiliary method for the treatment of malignant tumors and refers to killing the malignant tumor cells in patients by injecting effective immune cells into the patient without damaging the patient's own immune system.The DNT cells discovered in recent years,namely TCR +,CD3 +,CD4-,and CD8-T cells,are T-cell subpopulations with unique immunomodulatory functions,and their expression of Fas/FasL,TNF/TNFR,and MHCI,etc.They have an important role in anti-tumor,immune regulation,immunosuppression,etc.
