Research progress of pancreatic enzyme replacement therapy after gastric resection

VernacularTitle:胃切除术后胰酶替代治疗的研究进展
Author: Zhankun CUI ¹ ; Zhilei SU ; Shounan LU ; Wen FU ; Sheng TAI
Author Information

1. 150001,哈尔滨医科大学附属第二医院胆胰外科
Keywords: Gastrectomy; Exocrine pancreatic insufficiency; Dyspepsia; Pancreatic enzyme replacement therapy
From: International Journal of Surgery 2018;45(4):276-280
CountryChina
Language:Chinese
Abstract: Gastric resection can cause a multifactorial clinical manifestations of dyspepsia,such as flatulence,diarrhea,weight loss,and fat diarrhea.Exocrine pancreatic insufficiency (EPI) is one of the possible mechanisms of fat maldigestion following gastric surgery,the main causes may be related to rapid gastric emptying;asynchrony between gastric emptying and bilio-pancreatic secretion due to new tracts of various reconstructions;bacterial overgrowth after gastrectomy and so on.Oral pancreatic enzyme replacement therapy (PERT) is the mainstay of treatment for EPI,due to lack of available evidence so far,the efficacy and safety of pancreatic enzyme substitution in patients following gastric resection remains unclear and cannot be generally recommended.This review will sum up the revelant studies addressing EPI and PERT after gastric resection in recent years,and summarizes the mechanisms,clinical diagnostic methods and PERT treatment perscription of EPI after gastrectomy to improve the cognition of clinicans.