Correlation between changes of body fat distribution and insulin resistance after Roux-en-Y gastric bypass
10.3760/cma.j.issn.1673-4203.2018.04.004
- VernacularTitle:胃旁路术后体脂分布变化与胰岛素抵抗的关系
- Author:
Rao LI
1
;
Liyong ZHU
;
Pengzhou LI
;
Xiangwu YANG
;
Weizheng LI
;
Guangnian JI
;
Xulong SUN
;
Xianjie QIU
;
Shaihong ZHU
Author Information
1. 中南大学湘雅三医院普外科
- Keywords:
Gastric bypass;
Diabetes mellitus,type 2;
Body fat distribution;
Insulin resistance
- From:
International Journal of Surgery
2018;45(4):228-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of laparoscopic Roux-en-Y gastric bypass(LYGB) on body fat distribution,and relationship between the changes of body fat distribution and improvement of insulin resistance.Methods A total of 65 patients with type 2 diabetes who underwent LYGB were selected for a retrospective analysis.Metabolic parameters,anthropometric measurements,body composition and fat distribution measured by dual-energy X-ray absorptiometry (DEXA) were collected separately before and 6 months post LYGB.All data of pre-and postoperation were compared with pair t test,Pearson correlation analysis was used to evaluate correlation of two variables.Results Weight,body mass index,waist circumference,waist-to-hip ratio,triglyceride,fasting plasma glucose,fasting insulin and homeostatic model assessment for insulin resistance (HOMA-IR) were significantly decreased in 6 months after surgery (P ＜ 0.05).Total fat mass,body fat mass of trunk,upper and lower limbs decreased significantly (P ＜0.05).Percent fat mass at the whole body,Android region,upper and lower limbs decreased significantly (P ＜0.05).After 6 months postoperatively,abdominal obesity indices waist circumfernce decreased from (98.10±13.03) cm to (91.60±7.68) cm (P＜0.01) and percent fat mass at the Android region decreased from (35.71 ±10.24)％ to (29.44 ± 12.11) ％ (P＜0.05),HOMA-IR decreased from 3.62 ± 5.18 to 1.79 ± 1.52 (P ＜ 0.05).The improvement of postoperative insulin resistance is positively correlated with the changes in waist circumference (P ＜0.01) and percent fat mass of Android region (P ＜0.05).Conclusions The body fat distribution changes after LYGB,change of abdominal fat distribution is positively correlated to the improvement of insulin resistance.
