Research progress on the relationship between TET1 and tumor invasion and metastasis
10.3760/cma.j.issn.1673-4203.2018.01.017
- VernacularTitle:TET1与肿瘤侵袭转移关系的研究进展
- Author:
Mengmeng ZHANG
1
;
Lihua ZHENG
;
Xiangmei ZHANG
;
Yunjiang LIU
Author Information
1. 贵州医科大学附属医院乳腺外科
- Keywords:
Neoplasm metastasis;
Neoplasm invasiveness;
Ten-eleven translocation 1;
Epigenetics;
Epithelial mesenchymal transition
- From:
International Journal of Surgery
2018;45(1):65-68
- CountryChina
- Language:Chinese
-
Abstract:
TET1 has been discovered capable of promoting DNA demethylation by mediating 5-methylcytosine to inhibit the genesis and development of cancer.Epithelial-Mesenchymal transition is a complex cellular program in cancer progression and metastasis,whose hallmark is loss of cell polarity and cell adhesion and acquirement of migration and invasion abilities,leading tumor cells into blood vessel and lymphatic vessels to form new metastatic lesions.Epigenetics plays a vital role in epithelial-mesenchymal transition.This review focuses on the relationship of TET1,epigenetics and epithelial-mesenchymall transition,and the research progression of TET1's role in cancer invasion and metastasis.
