Application of graft-derived cell-free DNA to graft injuries after liver transplantation
10.3760/cma.j.issn.1673-4203.2018.01.016
- VernacularTitle:来源于移植物的游离DNA在肝移植术后移植物损伤中的应用进展
- Author:
Hairui WU
1
;
Liying SUN
;
Zhijun ZHU
Author Information
1. 100050,首都医科大学附属北京友谊医院肝移植中心
- Keywords:
Cell-free DNA;
Liver transplantation;
Graft injuries;
Rejection
- From:
International Journal of Surgery
2018;45(1):61-65
- CountryChina
- Language:Chinese
-
Abstract:
In China,the surgical technique of liver transplantation has become mature,however,the graft injuries,the personalized-adjustment of the immunosuppression and the rejection after the operation have been increasing prominently.Especially,the un-reversible chronic rejection and the side-effect of the over-dosage or under-dosage immunosuppression should be emphasized.Adopting the liver function examination and the liver-biopsy to monitor the graft function have disadvantages such as traumatic,time-consuming and low sensitivity.Recently,adopting the graft-derived cell-free DNA to monitor the graft health has becoming the research hotspots.The followings summarize the application of the graft-derived cell-free DNA after the operation.
