Progress of epithelial mesenchymal transition in breast cancer related signaling pathways
10.3760/cma.j.issn.1673-4203.2018.01.015
- VernacularTitle:上皮间质转化在乳腺癌相关信号通路中的研究进展
- Author:
Yulin LUO
1
;
Fenglin CAI
;
Haosheng TAN
;
Deyuan FU
Author Information
1. 中南大学湘雅二医院甲状腺乳腺外科
- Keywords:
Breast neoplasms;
Biological processes;
Epithelial msenchymal transition;
Signal transduction
- From:
International Journal of Surgery
2018;45(1):56-61
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial mesenchymal transition is a kind of important pathophysiological phenomenon,which refers to a biological processe that epithelial cell turns into another cell with mesenchymal phenotype undergoing a specific procedure.Once the tumor cell acquires mesenchymal cell molecular phenotype,it will enable stationary epithelial cells to gain the ability to migrate and invade as single cells,being easy to break away from the original tumor and move to the distal organs with blood flow.The occurrence of epithelial mesenchymal transition involves a variety of signal transduction pathways,which relates to inducing factors,transcription factors and so on.The occurrence and development of breast cancer is influenced by many factors and many signal transduction pathways.In recent years,the research of tumor suppressor and tumor resistance is more extensive.In this paper,a review of epithelial mesenchymal transition related signaling pathways in breast cancer is presented.
