Resistance mechanisms of tumour-initiating cells
10.3760/cma.j.issn.1673-4203.2017.12.017
- VernacularTitle:肿瘤起始细胞化疗耐药机制研究
- Author:
Guoqing PEI
1
;
Bojian JIANG
;
Jiwei YU
Author Information
1. 上海交通大学医学院附属第九人民医院普外科
- Keywords:
Neoplasms;
Drug resistance,neoplasms;
Tumor initiating cells;
Review;
Chemotherapy
- From:
International Journal of Surgery
2017;44(12):855-860
- CountryChina
- Language:Chinese
-
Abstract:
Tumor initiating cells are the source of the tumor,which have the characteristics of stem cells,such as self-renewal capacity,unlimited proliferation,multi-directional differentiation,DNA repair activity and resistance to apoptosis.The tumor initiating cells involved in chemotherapy drug resistance,traditional chemotherapy drugs is difficult to kill them,studies have shown that the tumor initiating cells involved in chemotherapy drug resistance.Tumor initiating cells are the significant factor of drug resistance and relapse in the tumor.tumor initiating cells resistance mechanism is complex,not only involved in tumor generally resistant characteristics,but kept natural resistance properties of stem cells.Tumor initiating cells resistant mechanism is controversial.This review introduces the resistance mechanisms of tumor-initiating cells both in tumor initiating cells-intrinsic and tumor initiating cells-extrinsic aspects based on the domestic and international relevant literatures.By revealing the drug resistance mechanism,it can be used to predict the effect of clinical chemotherapy,and now the article will review the research progress of the drug resistance mechanism of tumor initiating cells.
