Progress of research on therapy and characteristics of gene and protein for triple-negative breast cancer
10.3760/cma.j.issn.1673-4203.2017.10.019
- VernacularTitle:三阴性乳腺癌的基因和蛋白表达特点及其治疗方法的研究进展
- Author:
Yulong LI
1
;
Huiming DONG
Author Information
1. 蚌埠医学院第一附属医院肿瘤外科
- Keywords:
Breast neoplasms,triple-negative;
Genes;
Protein;
Therapy
- From:
International Journal of Surgery
2017;44(10):709-714
- CountryChina
- Language:Chinese
-
Abstract:
Triple-negative breast cancer,which lacks estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2,accounts for about 15％-20％ of breast cancers,and is the most aggressive breast cancer subtype.It displays poor prognosis from traditional therapies,therefore,there is an urgent need to find new treatments.This paper mainly describes the characteristics of protein and gene expression,such as PIM1,MYC,CDK4,TGF-β,TP53,MYOF,FOSB,MENA,and the latest research of therapeutic approaches of triplenegative breast cancer about PARP,PI3K/Akt/mTOR,EGFR,Hedgehog,Met,etc..
