A Case of Acute Renal Failure Following Intravenous Immunoglobulin Therapy in a Child.
- Author:
Sung Wook PARK
1
;
Kyung Yil LEE
;
Joo Ok LEE
;
Kye Nam YOON
;
Sang Won CHA
;
Dong Jun LEE
;
Ji Whan HAN
;
Kyung Tai WHANG
Author Information
1. Department of Pediatrics, College of Medicine, Catholic University of Korea.
- Publication Type:Original Article
- Keywords:
Acute renal failure;
Intravenous immunoglobulin;
Child;
Kawasaki disease
- MeSH:
Acute Kidney Injury*;
Body Weight;
Child*;
Child, Preschool;
Creatinine;
Female;
Humans;
Immunization, Passive*;
Immunoglobulins*;
Immunoglobulins, Intravenous;
Maltose;
Mucocutaneous Lymph Node Syndrome
- From:Journal of the Korean Pediatric Society
2000;43(5):720-724
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Intravenous immunoglobulin (IVIG) therapy is associated with a number of complications, including rare acute renal failure (ARF). Although the cause of IVIG-associated ARF is unknown, it may be related to the stabilizing agent used in IVIG preparations. ARF following IVIG infusion has not been previously described in children. We report a 4-year-old girl with Kawasaki disease who suffered from ARF following IVIG containing maltose. The previously healthy child had no underlying renal disease. She was given a 2g/kg body weight of IVIG (I.V.-Globulin S, Green Cross, IgG:maltose=1:2) for 10 hours. From the second day of IVIG administration, a gradual reduction of daily urine output was observed with an increase of BUN and creatinine levels, which by the fourth day of treatment reached 43.8mg/dL and 4.7mg/dL, respectively. A conservative ARF treatment resulted in a gradual increase in urine output, together with a decrease in BUN and creatinine levels, which after 7 days returned to normal levels. In view of the increasing use of IVIG in medicine, it is imperative that clinicians be aware of this unusual form of renal injury.
