Advantages and feasibility of intraperitoneal insulin delivery
10.3760/cma.j.issn.1673-4181.2018.04.015
- VernacularTitle:胰岛素腹腔给药的优势及可行性
- Author:
Ting XIA
1
;
Guanxin GAO
;
Huilin XIA
;
Hong ZHANG
;
Tao YANG
;
Yuefei LI
;
Jian ZHONG
;
Hongfan SUN
Author Information
1. 010010,内蒙古自治区人民医院医学工程处
- Keywords:
Insulin;
Intraperitoneal delivery;
Lipid metabolism;
Diabetes
- From:
International Journal of Biomedical Engineering
2018;41(4):354-358,364
- CountryChina
- Language:Chinese
-
Abstract:
Under normal conditions,insulin secreted by the pancreas enters the liver through the portal vein,forming a difference in insulin concentration above the peripheral circulation.Subcutaneous administration of insulin forms a portal-peripheral concentration gradient of insulin above the liver,which is inconsistent with normal physiological conditions.Intraperitoneal insulin administration has been extensively investigated because that is closer to physiological state.In this paper,the pharmacokinetic and pharmacodynamic studies of insulin intraperitoneal administration were reviewed.Compared with the conventional subcutaneous delivery,intraperitoneal insulin administration can not only reduce the incidence of hypoglycemia,but also has the advantage of correcting abnormal lipid metabolism.This means that intraperitoneal administration of insulin has a positive effect on the prevention and treatment of diabetic complications.Therefore,it is necessary and feasible to develop a safe,low-cost,and easy-to-use percutaneous intraperitoneal insulin delivery device.
