Verification of small intestinal submucosa graft stent in vitro
10.3760/cma.j.issn.1673-4181.2018.04.002
- VernacularTitle:小肠黏膜下层覆膜支架体外验证实验研究
- Author:
Lixue LIU
1
,
2
;
Xuelian GU
;
Wenjing TANG
;
Xue FAN
Author Information
1. 200093 上海理工大学教育部微创医疗器械工程研究中心
2. 200093 上海理工大学医疗器械与食品学院
- Keywords:
Biological graft;
Small intestine submucosa;
Graft stent;
In vitro test
- From:
International Journal of Biomedical Engineering
2018;41(4):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify the feasibility of using small intestine submucosa for graft stents.Methods A Z-type Nitinol wire stent was used as the metal stent material,and porcine small intestine submucosa was used as the biofilm material to prepare the bio-coated stent.In vitro implantation,extracorporeal pulsation and extracorporeal flexion of the stents were designed based on the requirements for the small intestine submucosa graft stent implantation during the endovascular aneurysm repair and of the mechanical properties of the graft stent during human body activity.The feasibility of using small intestine submucosa for the graft stents was evaluated according to the patency of the stent lumen after the experiment,the presence or absence of cracks in the membrane,and the presence or absence of fracture of the metal stent.Results In the in vitro experiments,all the samples were able to maintain complete tunica and luminal patency except the 8th sample that showed suture rupture.Besides,all the samples showed good rebounding and adhering properties in both in vitro implantations and extracorporeal pulsation pressure experiments,and no dangerous problems were found such as film rupture,suture loss and stent fracture.Conclusion Small intestine submucosa can meet the durability requirements of graft stents,adapt to the conditions of graft stents such as implantation,bending and blood pulsation,and can be used as the covering material of graft stents.
