Radioprotective effect of ATP on mice irradiated with a lethal dose of γ-ray
10.3760/cma.j.issn.1673-4181.2018.01.009
- VernacularTitle:三磷酸腺苷对高剂量γ射线照射小鼠的防护作用研究
- Author:
Changchun ZHU
1
;
Guoxing FENG
;
Ming CUI
;
Mian JIANG
;
Junbo HE
;
Saijun FAN
Author Information
1. 300192天津,中国医学科学院北京协和医学院放射医学研究所,天津市放射医学与分子核医学重点实验室
- Keywords:
Adenosine triphosphate;
Ionizing radiation;
Radioprotective effect
- From:
International Journal of Biomedical Engineering
2018;41(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the in vivo radioprotective effect of adenosine triphosphate (ATP) on radiation damage induced by high dose γ-ray ionizing radiation(IR) in mice.Methods Specific pathogen-free C57BL/6 female mice were randomly divided into IR group and IR+ATP group by body weight,with 10 mice in each group.All the mice were treated with a 8 Gy one-time and high-dose whole body γ-ray irradiation.Within 6 h after irradiation,mice were injected intramuscular injection of 150 pl sodium chloride solution (9 g/L) for IR group,and 150 μl ATP solution (6 mg/kg) for IR+ATP group,respectively.The drug was administered once a day until the death of the animal.The mean survival days,survival rate,body weight and major organ coefficients in both groups were measured.Results The average survival days of mice in IR group and IR +ATP group were 6.5 d and 9.6 d,respectively.The survival rate of the mice in IR+ATP group was higher than that in IR group (P＜0.01).The body weight values of the mice in IR+ATP group was higher than that in IR group on the after the 4th day post-irradiation,and the differences were statistically significant (all P＜0.05).Except for heart and stomach,the organ coefficients of liver,spleen,lung,and kidney in IR +ATP mice were higher than those in IR group,and the differences were statistically significant (all P＜0.05).Conclusion ATP has certain radiation protection effect,and it can reduce the radiation damage of mice induced by high-dose (8 Gy) γ-ray IR so as to increase the survival rate.
