Roles and mechanisms of connexin 43 in cerebral ischemia-reperfusion
10.3760/cma.j.issn.1673-4165.2018.09.011
- VernacularTitle:缝隙连接蛋白43在脑缺血再灌注中的作用及其机制
- Author:
Kongping LI
1
;
Jianhua ZHENG
;
Xiaohui CHEN
;
Minhua FANG
;
En XU
Author Information
1. 广州医科大学附属第二医院神经内科
- Keywords:
Brain Ischemia;
Reperfusion Injury;
Gap Junctions;
Connexin 43;
src-Family Kinases;
Zonula Occludens-1 Protein;
Excitatory Amino Acid Transporter 2;
Ion Channels;
Cell Death;
Neuroprotection
- From:
International Journal of Cerebrovascular Diseases
2018;26(9):708-716
- CountryChina
- Language:Chinese
-
Abstract:
In the central nervous system, gap junctions exist between neurons and glial cells. Among them, connexin 43 (Cx43) is one of the most abundant connexin proteins in the central nervous system,involved in the metabolic coupling of intercellular substance exchange and electrical coupling of electrical signaling. It plays an important role in regulating cell metabolism, homeostasis, and cell differentiation. After cerebral ischemia, the uncoupling of gap junctions and abnormal hemichannel activity cause a steady-state imbalance of the internal and external environment of the cells, eventually leading to brain tissue damage.Therefore, maintaining the normal function of Cx43 is essential for protecting brain tissue from neuronal damage induced by cerebral ischemia-reperfusion.
