Effect of serum uric acid level on outcomes after intravenous thrombolysis in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2018.09.004
- VernacularTitle:血清尿酸水平对急性缺血性卒中患者静脉溶栓治疗后转归的影响
- Author:
Zhihao LEI
1
,
2
;
Shisheng YE
;
Pinghui ZENG
;
Lijie REN
Author Information
1. 518000 深圳市第二人民医院(深圳大学附属第一医院)神经内科
2. 510000 广州,中山大学孙逸仙纪念医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Uric Acid;
Thrombolytic Therapy;
Neuroprotective Agents;
Treatment Outcome
- From:
International Journal of Cerebrovascular Diseases
2018;26(9):666-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of serum uric acid level on outcomes after intravenous thrombolysis in patients with acute ischemic stroke. Methods From April 2014 to January 2018I, patients with acute ischemic stroke received intravenous thrombolysis at the stroke unit of Shenzhen Second People's Hospital were enrolled retrospectively. The clinical outcomes were assessed according to the modified Rankin scale at 3 months after onset, > 2 were defined as poor outcome. The demographic and clinical data were compared between the good outcome group and the poor outcome group. Multivariate logistic regression analysis was used to determine the independent influencing factors of clinical outcomes. Results A total of 155 patients were enrolled, including 92 (59. 4％) in the good outcome group and 63 (40. 6％) in the poor outcome group. The serum uric acid level in the good outcome group was significantly higher than that in the poor outcome group (365. 465 ±100. 055 μmol/L vs. 325. 958 ±114. 704 μmol/L; t = -2. 227,P = 0. 027). Multivariate logistic regression analysis showed that there was a significant positive correlation between low serum uric acid levels and poor outcomes (They were divided into 4 levels according to the quantiles. ≥416. 01 μmol/L as reference; 350. 11- 416. 00 μmol/L: odds ratio [ OR ] 1. 414, 95％ confidence interval [CI] 0. 375-5. 339, P = 0. 609; 278. 61-350. 10 μmol/L: OR 3. 020, 95％ CI 0. 878- 10. 390, P = 0. 080; ≤ 278. 60 μmol/L: OR 4. 194, 95％ CI 1. 194-14. 726, P = 0. 025; trend test P =0. 013]. Conclusion Higher serum uric acid level is independently associated with good outcomes after intravenous thrombolysis in patients with acute ischemic stroke.
